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NC3Rs/HSE/BTS Workshop: Increasing confidence in New Approach Methodologies for regulatory decision-making
In collaboration with the British Toxicology Society and the Health and Safety Executive’s Chemicals Regulation Division, the NC3Rs is hosting a two-day virtual workshop on 23-24 February 2022. The workshop will be chaired by Professor John Colbourne, University of Birmingham and Professor Alan Boobis, Imperial College London.

New approach methodologies (NAMs) have great promise in providing useful information for chemical hazard and risk assessment. In the last decade, significant investment has been made in developing new tools that can reduce reliance on animals and improve decision-making in chemical safety assessments, including computational models, read-across and grouping approaches, microphysiological systems and ‘omics’ technologies. However, there is often a lack of confidence in applying these methods within a regulatory setting, and uptake for hazard identification and characterisation of complex endpoints requires further development. A focus on methods that provide a better understanding of mechanisms behind adverse effects (i.e. AOPs – adverse outcome pathways), and that incorporate exposure science will support a move away from traditional tests in animals and potentially provide more relevant safety assessments.

The workshop aims to raise awareness of currently available NAMs and explore how regulatory application and acceptance of these tools can be accelerated by overcoming the most significant barriers to their implementation.

The meeting is relevant for academic, regulatory and industry scientists with an interest in the development and application of NAMs.
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