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10 years of CRACK IT webinar: The worm that turned the tide on in vivo DART testing
This webinar forms part of the CRACK IT 10 year anniversary celebrations and will showcase a C. elegans platform to assess the developmental and reproductive toxicity (DART) potential of chemicals developed to address the 2012 PreDART CRACK IT Challenge.

The C. elegans model, when used in combination with a zebrafish embryo screen also developed during the Challenge, correctly identified 100% of well characterised DART chemicals provided by the Challenge Sponsors (Shell and Syngenta). Testing in these two model organisms is cheap and fast, taking one week to complete compared to mammalian studies conducted to comply with OECD test guidelines which can take up to 30 weeks and use large numbers of rodents and rabbits.

During the webinar you will hear from:

Dr Marjolein Wildwater, Founder and General Director of Vivaltes, the company spun out to commercialise the research developed during the PreDART Challenge. Marjolein will describe the technology development process and the role that CRACK IT played in supporting the creation of a commercial ready product.

Dr Martijn Rooseboom (Shell). Martijn was one of the original Sponsors who set and helped deliver the PreDART Challenge. During his presentation, Martijn will describe the reason for setting the Challenge, the role of the Sponsor and how Shell has continued to apply the C. elegans platform to support their product development. He will also describe the wider scientific and 3Rs impacts of this compared to traditional in vivo approaches.

There will be an opportunity to ask questions after the webinar presentation. The webinar is free to attend.

Further information about the Vivaltes platform and PreDART Challenge can be found on the NC3Rs Innovation Platform: https://nc3rs.org.uk/crackit/predart

Mar 16, 2021 02:00 PM in London

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